Browsing by Subject "ABCA1-DEFICIENT MACROPHAGES"

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Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages

Zhu, Xuewei; Lee, Ji-Young; Timmins, Jenelle M.; Brown, J. Mark; Boudyguina, Elena; Mulya, Anny; Gebre, Abraham K.; Willingham, Mark C.; Hiltbold, Elizabeth M.; Mishra, Nilamadhab (2021-03-23)

Macrophage-specific Abca1 knock-out (Abca1(-M/-M)) mice were generated to determine the role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate immune response of macrophages. Plasma lipid ...

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

Zhu, Xuewei; Owen, John S.; Wilson, Martha D.; Li, Haitao; Griffiths, Gary L.; Thomas, Michael J.; Hiltbold, Elizabeth M.; Fessler, Michael B.; Parks, John S. (2022-03-11)

We previously showed that macrophages from macrophage-specifi c ATP-binding cassette transporter A1 (ABCA1) knockout (Abca1(-M/-M)) mice had an enhanced proinflammatory response to the Toll-like receptor (TLR) 4 agonist, ...